shown as gray chains of actin molecules (balls), covered with smooth tropomyosin filaments. Troponin is shown in red (subunits not distinguished). Upon binding calcium, troponin moves tropomyosin ...

Calcium is required by two proteins, troponin and tropomyosin, that regulate muscle contraction by blocking the binding of myosin to filamentous actin. In a resting sarcomere, tropomyosin blocks ...

Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties and tropomyosin’s ability ...