The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

The rationale behind the angiotensin receptor-neprilysin inhibitor (ARNI) combination should also be mentioned (4): Neprilysin breaks down angiotensin II; thus, it would be counterproductive to ...

Angiotensin-Converting Enzyme (ACE) Inhibitors and Angiotensin Receptor Blockers (ARBs ... ARNIs are a combination of two drugs: a neprilysin inhibitor and an ARB. A neprilysin inhibitor helps ...

of the left ventricle if they had been randomly assigned the angiotensin receptor-neprilysin inhibitor (ARNI) treatment for 24 weeks instead of placebo (7.1% vs 25%, OR 0.23, 95% CI 0.07-0.75 ...

Current treatments for HFpEF for women include angiotensin receptor-neprilysin inhibitors, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2) inhibitors and GLP-1 ...

and the action of the angiotensin II molecule, once synthesized, can be blocked at the receptor. In practice, only ACE inhibitors and ARBs have provided safe and effective management of ...