induction of B-cell inhibitory receptors; interruption of signaling through the B-cell receptor (BCR) or co-stimulatory receptors (or both); and deletion or functional inactivation of antigen ...

The binding affinity of the Fc fragment towards ... evoke antibody-dependent cell-mediated cytotoxicity (ADCC). Thus, candidates should be tested against a panel of receptors at the time of ...

Previous studies established defective Fc receptor mediated clearance in patients ... other than SLE reflect enhanced reticuloendothelial cell function and not the depressed clearance function ...

The US biotech aims to bring its antibody-based therapies to human trials later in the year and to develop new candidate ...