The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK ...

Researchers from SRM Institute of Science and Technology, led by Dr. KN Aruljothi, have published a study in ExRNA ...

The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...

It is also critical for signal transduction pathways and is reversible ... models of phosphorylation sites and has identified CDK regulation by MTOR. Furthermore, a global analysis using a ...

What are the functions of Cdk's and Cyclins? How are they involved in cell cycle regulation ... What roles do the various types of receptors and signal transduction pathways play in the activation of ...