However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

Together with Tabrizi’s study, the findings converge on the idea that MSH3 and other DNA mismatch repair enzymes accelerate CAG expansion, and thus degeneration, in HD-vulnerable neurons. Both Tabrizi ...

Diets low in carbohydrates and soluble fibres can drive the growth of polyps in the colon, increasing the risk of developing ...

These strains had genetic changes in genes that control the fungus's system which repairs mutated DNA—known as the mismatch repair system. By using CRISPR-Cas9 to reproduce these variants in the ...

Researchers from the University of Toronto have shown how a low-carbohydrate diet can worsen the DNA-damaging effects of some ...

coupled with inadequate DNA mismatch repair systems, can produce deletions or insertions of repeat units. Bulging in the replicated and template strands gives rise to larger and smaller numbers of ...

University of Toronto researchers have shown how a low carbohydrate diet can worsen the DNA-damaging effects of some gut ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

Researchers have shown how a low carbohydrate diet can worsen the DNA-damaging effects of some gut microbes to cause colorectal cancer. The study compared the effects of three different diets in ...