Diabetic nephropathy remains a major complication ... It examines the impact of mTOR on podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells ...

A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...

Polycystic kidney disease (PKD), a family of genetic disorders that causes clusters of cysts to form on the kidney, is among the most common genetic disorders, affecting some 500,000 people in the ...

Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine by renal tubular secretion. The addition of cimetidine 400 mg to metformin 250 mg ...