New small-molecule inhibitors are being developed as well; Basel-based Novartis received approval for Tekturna (aliskiren), a direct renin inhibitor, just last year. Aldosterone synthesis ...

These agents include angiotensin-converting-enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), mineralocorticoid-receptor antagonists, and direct renin inhibitors, all of which can ...

If the clinical history is not helpful (e.g., there is no documentation of the efficacy of drug "A"), then measuring a renin level (either plasma renin activity or direct renin) can be helpful ...