In this study, we investigated the mechanisms by which high mobility group box protein 1 (HMGB1) acts to accelerate muscle fatigue development. Results Our results demonstrate that TLR4 is expressed ...
Previous studies have demonstrated the close relationship between NPSLE and inflammation. HMGB1-TLR4 signaling pathway is the up-stream pathway of NF-κB, which could upregulate the expression of ...
Meanwhile, HMGB1, by binding to TLR4, not only directly promotes the migration of HIF-1 to the nucleus to exert transcriptional regulation but also activates the MYD88/NF-κB pathway to enhance the ...
Recent studies reported an interplay between the receptor for advanced glycation end products (RAGE) and its ligands, S100 protein group, advanced glycation end products (AGEs) and high-mobility group ...
The guiding hypothesis for this objective is that surgery releases the danger associated molecular pattern high mobility group box-1 protein (HMGB1) in specific brain regions, and that this protein ...
Introduction High Mobility Group Box-1 (HMGB1) is a ubiquitous nuclear protein that regulates gene expression. When phosphorylated, it translocates to the cytoplasm and extracellular space to ...