In this study, we investigated the mechanisms by which high mobility group box protein 1 (HMGB1) acts to accelerate muscle fatigue development. Results Our results demonstrate that TLR4 is expressed ...
HMGB1是一种宿主源性蛋白,通过作用于TLR4引发炎症反应,与多种炎症性疾病的发病机制相关。本研究设计的非复制性AdV载体,可在LPS和流感诱导下产生HMGB1 Box A,有效减轻巨噬细胞中的炎症,并在小鼠和大鼠模型中保护动物免受流感病毒感染,为多种疾病治疗 ...
Previous studies have demonstrated the close relationship between NPSLE and inflammation. HMGB1-TLR4 signaling pathway is the up-stream pathway of NF-κB, which could upregulate the expression of ...
NEC患儿肠道中的TLR4导致细胞释放出另外一种蛋白质HMGB1。该团队通过基因工程让小鼠体内缺乏HMGB1,然后让其患上NEC。这些小鼠大脑中小胶质细胞 ...
Meanwhile, HMGB1, by binding to TLR4, not only directly promotes the migration of HIF-1 to the nucleus to exert transcriptional regulation but also activates the MYD88/NF-κB pathway to enhance the ...
Recent studies reported an interplay between the receptor for advanced glycation end products (RAGE) and its ligands, S100 protein group, advanced glycation end products (AGEs) and high-mobility group ...
The guiding hypothesis for this objective is that surgery releases the danger associated molecular pattern high mobility group box-1 protein (HMGB1) in specific brain regions, and that this protein ...
Introduction High Mobility Group Box-1 (HMGB1) is a ubiquitous nuclear protein that regulates gene expression. When phosphorylated, it translocates to the cytoplasm and extracellular space to ...