HMGB1是一种宿主源性蛋白，通过作用于TLR4引发炎症反应，与多种炎症性疾病的发病机制相关。本研究设计的非复制性AdV载体，可在LPS和流感诱导下产生HMGB1 Box A，有效减轻巨噬细胞中的炎症，并在小鼠和大鼠模型中保护动物免受流感病毒感染，为多种疾病治疗 ...

Toll-like Receptor 4 (TLR4): A protein that plays a key role in the immune system by recognizing pathogens and activating inflammatory responses. High Mobility Group Box 1 (HMGB1): A protein that ...

NEC患儿肠道中的TLR4导致细胞释放出另外一种蛋白质HMGB1。该团队通过基因工程让小鼠体内缺乏HMGB1，然后让其患上NEC。这些小鼠大脑中小胶质细胞 ...

The guiding hypothesis for this objective is that surgery releases the danger associated molecular pattern high mobility group box-1 protein (HMGB1) in specific brain regions, and that this protein ...