As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

肝脏是人体再生能力最强的实体器官。然而，持续的慢性肝损伤会显著抑制肝脏再生能力，进而导致肝纤维化的发生。肝星状细胞（Hepatic stellate ...

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver ...

Inflammation and cell death are key triggers of hepatic fibrogenesis in NAFLD, with hepatic stellate cells (HSCs) playing a ...

Liver siRNA is under clinical development by Nitto BioPharma and currently in Phase II for Liver Cancer. According to GlobalData, Phase II drugs for Liver Cancer have a 31% phase transition success ...

Chronic liver damage can lead to hepatitis, which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during ...

2017 Exosome mediated intercellular communication between hepatitis C virus infected hepatocytes and hepatic stellate cells. J Virol. 91(6). pii: e02225-16. PMCID: PMC28077652 Sasaki R, Devhare PB, ...