and the BRCA2 protein that binds to the resected ssDNA (Yang et al., 2002) and catalyzes the formation of the nucleoprotein filament by the RAD51 recombinase (Yang et al., 2005). View of an ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Our long-term goals are to exploit the molecular genetic systems we have developed to understand the role of homologous recombination in maintaining genetic stability. We are determining factors that ...

Published in Clinical Cancer Research, results of a VHIO-led study underscore the potential of the RAD51 biomarker in ...

Developed in-house by Serra’s laboratory, a test based on the detection of the RAD51 protein as a functional biomarker of ...

Our research is focused on uncovering the role of such helicases in complex DNA manipulations, such as the processing of broken DNA for repair by homologous recombination. We are also interested in ...

In Meiosis I homologous chromosomes separate, which requires pairing ... with the complex chromosome structure and proteins that are required to pair and segregate homologs (synaptonemal complex, ...

Investigators at the Third People’s Hospital of Chengdu and collaborators described the synergistic effect obtained by the combined administration of LB-23, a PARP1 degrader, and JQ1, a BRD4 inhibitor ...

Within every cell in our body, our DNA is tightly bundled with proteins to form structures ... During reproduction, ...