eLife1d
A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception
This important study examined orientation representations along the visual hierarchy during perception and working memory. The authors provide results suggesting that during working memory there is a ...
eLife2d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
eLife3d
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
eLife2d
Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced pain facilitation
Here, we identified a circuit, locus coeruleus descending noradrenergic neurons projecting to the spinal dorsal horn (LC →SDH -NA neurons), that is activated by acute exposure to restraint stress and ...
eLife3d
Activism and Science: Anne Urai and Clare Kelly on responding to the climate and biodiversity crises
Yes, identifying your audience workshop is very important. A type A audience is already engaged – they understand the urgency ...
eLife2d
Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...
eLife3d
Motor unit mechanisms of speed control in mouse locomotion
This valuable study characterises the activity of motor units from two of the three anatomical subdivisions ("heads") of the triceps muscle while mice walked on a treadmill at various speeds. Although ...
eLife3d
Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep
Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.
eLife3d
Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...
eLife3d
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...
eLife3d
Founder effects arising from gathering dynamics systematically bias emerging pathogen surveillance
The evidence is convincing in terms of the soundness of the theoretical projections and the impact that accounting for group sizes may have on inferences from surveillance data. However, it has not ...
eLife1d
Metabolism: Insulin control in fruit flies
Investigating how the production of insulin is regulated in fruit flies reveals surprising insights that may help to better understand how this process unfolds in humans.