NFTs, which are composed of misfolded tau proteins, represent a key outcome of a dynamic process, much like Aβ plaques are the outcome of the amyloid cascade. However, the question of whether Aβ ...

Alzheimer's disease may be the most common dementia, but amyloid-beta (Aβ) plaques and tau tangles don't tell the whole story of its complex pathobiology. The disease is defined in part by two ...

Since amyloid-beta (Aβ) pathology often precedes tau abnormalities in AD, most biomarker efforts have focused on early detection of Aβ changes. However, the clumping of tau protein into the NFT ...

While both sexes show similar levels of Aβ burden, studies indicate that women may be more susceptible to tau pathology, a protein linked to neurodegeneration and cognitive decline. Previous ...

Alzheimer's disease is the most common form of dementia, characterized by the accumulation of amyloid-beta (Aβ) and tau proteins in the brain, leading to cognitive decline. Traditionally ...

To record the trends in beta-amyloid (Aβ) and tau protein accumulation, PET scans were conducted over a median of 4.5 years and 3.5 years, respectively, and imaging included the frontal ...

Researchers indicate that the Lumipulse p-tau217 assay may reduce over 50% of lumbar punctures performed for diagnosing Alzheimer's disease.

Mediation analysis confirmed that protofibrils fully explained the relationship between parenchymal amyloid and CSF Aβ. The same thing held true in APP NL-G-F knock-in mice. What about other CSF ...

Proteolytic processing of APP. Aβ plaques are accumulations of molecules in the extracellular space of the brain. The principal proteinaceous component of the plaques is the Aβ peptide ...