此外，通过双特异性 CAR-T 细胞同时靶向 CD13 和其他抗原，有可能减少脱靶毒性，为 AML 的治疗提供了新的思路。 LILRB4：急性单核细胞白血病（FAB M5）是 AML 的一种亚型，现有治疗方法效果不佳。LILRB4 在单核细胞白血病细胞上高度表达，且在正常造血干细胞上不 ...

进一步研究表明，LILRB4可通过与载脂蛋白E（ApoE）结合，调控小胶质细胞的活动。研究人员使用携带人类LILRB4转基因且具有淀粉样蛋白β（Aβ ...

Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle cerebral artery occlusion (MCAO), but the role it plays here is not well ...

5 Donghai Middle Road, Qingdao, Shandong Province 266071, China; yu-jintai{at}163.com Objective We aimed to examine the association of apolipoprotein E (APOE) ɛ4 genotype with neuroimaging markers of ...

Objective: Microglia, the central nervous system's immune cells, are crucial in neuroinflammation after ischemic brain injury. Previous single-cell and spatial transcriptomics showed that LILRB4 was ...

Introduction: Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a crucial regulator of immune responses, particularly within microglia, where it may influence the infiltration of peripheral T ...

Nature Research Intelligence Topics enable transformational understanding and discovery in research by categorising any document into meaningful, accessible topics. Read this blog to understand ...