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生物通
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TIGIT在肝外胆管癌中的表达及其对CD8 + T细胞耗竭的影响:免疫治疗的 ...
论文摘要指出,研究人员通过单细胞 RNA 测序(scRNA - seq)分析 ECCA 肿瘤浸润淋巴细胞(TILs),发现 TIGIT(T 细胞免疫球蛋白和免疫受体酪氨酸抑制基序结构域蛋白)在 TOX + CD8 T 细胞中显著高表达。组织微阵列和免疫组化染色显示,TIGIT 高表达与患者生存率降低 ...
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