Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

The repeating unit of chromatin, the nucleosome, consists of approximately 147 base pairs of DNA wrapped around eight histone protein cores. Linker DNA, upwards of 80 base pairs long, connects two ...

Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.

In the pursuit of understanding the pathogenic expression mechanisms of bacteria and the advancements in biofoundry ...

Chromatin is one of the most complex materials in cells and enables the massive amount of DNA in the genome to fold up and fit into the nucleus of each cell. The building blocks of this genetic ...

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More information: Irina V Zhegalova et al, Convergent pairs of highly transcribed genes restrict chromatin looping in Dictyostelium discoideum, Nucleic Acids Research (2025). DOI: 10.1093/nar/gkaf006 ...

The ability to control chromatin accessibility - how tightly DNA is packed in the cell nucleus - is ... Its sequence context expanded from 8,000 to 1 million base pairs, enabled partly by the new ...

Researchers at the Arc Institute, Stanford University, and NVIDIA have developed Evo 2, an advanced AI model capable of ...

With over 200 collectible sync pairs of Pokemon and their masters, it sure can get confusing for new players and veterans alike to come to a definitive conclusion about which ones are the best and ...

The applied physicist explains how the structure of 52,000-year-old genes hint at the biology of an extinct animal ...