However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

Researchers from the University of Toronto have shown how a low-carbohydrate diet can worsen the DNA-damaging effects of some ...

Scientists have identified strains of one of the world's most dangerous fungal pathogens, already resistant to our most effective antifungal drugs, which are also five times more likely to acquire ...

2025). Here, too, knockouts for MSH3 or the mismatch repair protein Pms1 most strongly affected HD phenotypes, including reduction of CAG expansion in striatal neurons, lowering of mouse Htt ...

Diets low in carbohydrates and soluble fibres can drive the growth of polyps in the colon, increasing the risk of developing ...

Microsatellite instable–high (MSI-H) tumors with deficient mismatch repair (dMMR) display a strong dependence on DHX9, making this helicase an attractive target for oncology drug discovery. In this ...

These effects were especially strong in subjects with genetic mutations in the mismatch repair pathway that hindered their ...