Diabetic nephropathy remains a major complication ... It examines the impact of mTOR on podocytes, glomerular mesangial cells, renal tubular epithelial cells, and glomerular endothelial cells ...

Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine by renal tubular secretion. The addition of cimetidine 400 mg to metformin 250 mg ...