Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Deletions and duplications of single-base pairs typically arise during homologous recombination and cause diseases. But what happens when a mutation occurs over multiple genes? Deletions involve ...

This interaction suggests that ILF3 may facilitate the resolution of telomeric R-loops, thereby preventing abnormal homologous recombination and maintaining telomere homeostasis. The work ...

Mol Cell Biol. 1998;18:93-101. Johnson RD, Liu N, Jasin M. 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature. 1999;401:397-399.

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

Sensitive tissue-based detection of AR-V7 and other androgen receptor alterations using combined DNA/RNA comprehensive genomic profiling.

LAE120 is a novel, allosteric and highly potent USP1 inhibitor, displaying monotherapy potency and combination activity with ...

with or without homologous recombination repair, or HRR, gene mutations, according to a statement. The TALAPRO-2 study consisted of two cohorts, with Cohort 2 evaluating patients selected for HRR ...