Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. 1998 Gene conversion tracts from double-strand break repair in mammalian cells in mammalian cells. Mol Cell Biol. 1998;18:93-101. Johnson ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

This interaction suggests that ILF3 may facilitate the resolution of telomeric R-loops, thereby preventing abnormal homologous recombination and maintaining telomere homeostasis. The work ...

Mayo Clinic's Precision Mouse Engineering Core in Minnesota makes embryonic stem (ES) cell-based gene-targeted mice available to researchers.

LAE120 is a novel, allosteric and highly potent USP1 inhibitor, displaying monotherapy potency and combination activity with ...

with or without homologous recombination repair, or HRR, gene mutations, according to a statement. The TALAPRO-2 study consisted of two cohorts, with Cohort 2 evaluating patients selected for HRR ...