Macbecin II was identified as a compound that upregulates MHC-I expression, enhancing immune-mediated cancer cell killing. In ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

However, cell therapy applications prefer serum-free media because they provide greater consistency and are often required to meet regulatory standards. In this application note, explore how ...

CXC-chemokines are upregulated in AH, and we previously found increased co-regulation of these genes in response to LPS in AH patients, using single cell data of monocytes 20. Zooming into the hotspot ...

Introduction: HIV-1 exploits dendritic cells (DCs) to spread throughout the body via specific recognition of gangliosides present on the viral envelope by the CD169/Siglec-1 membrane receptor. This ...

Asthma is a T helper 2 (T H 2)-cell-mediated disorder characterized by airway eosinophilia, goblet-cell hyperplasia and bronchial hyper-reactivity. Dendritic ... as allergens (derived, for example ...

Kent Kiehl and his research team regularly park their long, white trailer just outside the doors of maximum-security prisons across the US. Inside the vehicle sits the bulky body of a mobile MRI ...

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8 + T cell immune responses. Here, we show that this ...

Acute graft- vs. -host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs ...