This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Hence, various pathologies in adults may be considered diseases of abnormal development and differentiation. Embryonic development is marked by successive well-orchestrated differentiation events ...

This research highlights the potential of stem cells to not only model embryonic development but also to provide insights into the mechanisms that drive these processes. In addition to mouse ...

AUTS2 syndrome patients often exhibit microcephaly, yet its etiological mechanism remains unclear. This study reveals that ...

Here we bio-printed mesenchymal stem cells (MSCs) using a commonly used bioink sodium alginate-gelatin blends, and investigated the induction effect of MSC differentiation towards lens epithelial stem ...

Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research ...

Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the ...