Using transgenically tagged maternal or somatic ribosome subunits, we experimentally confirm the presence of hybrid 80S ribosomes composed of 40S and 60S subunits from both origins and demonstrate the ...

Prokaryotic translation often occurs ... of the polypeptide chain from the ribosome. The ribosome then disassembles into its two subunits. Proteins execute diverse cellular functions crucial ...

Proteolysis in bacteria is important not only for protein homeostasis and quality control (general proteolysis), but also for the control of regulatory processes such as adaptation and cell ...

Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation ...

G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA or RNA sequences. They play various regulatory roles in many biological processes. It is commonly agreed that G4 ...

Signalling Research Centers BIOSS and CIBSS, Faculty of Biology, and SGBM - Spemann Graduate School of Biology and Medicine, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...