Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

Autophagy is an essential cellular homeostasis mechanism that was found to be deficient in ageing and osteoarthritic cartilage. This study determined whether pharmacological inhibition of the ...

is highly sensitive to rapamycin, making it a key target for mTOR inhibitors, particularly first-generation inhibitors (Hay and Sonenberg, 2004). Understanding the biological complexities of the PAM ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...

The specific rapamycin-induced interaction between domains from mTOR and FKBP12 is also frequently employed in cell biological research ... These findings identify a novel molecular target for ...

In this study, the clinical significance and related mechanisms of TOX in CRC were investigated. Given that TOX inhibits mTOR signaling pathway activation, we also describe the combined effects of ...

But now Bowen Tan, Kristina Hedbacker, and other researchers in Friedman's Laboratory of Molecular Genetics have discovered a neural mechanism ... mTOR (short for "mammalian target of rapamycin").