indicating that it is not a cell-intrinsic mechanism but delivery of rapamycin to tumour cells that is impaired in some patients. As mTOR inhibitors can inhibit a negative feedback loop that ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though ...

Rapamycin is used to prevent graft rejection ... at the transcriptional level through at least two independent mechanisms. mTOR was shown to limit the production of pro-inflammatory cytokines ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

This study provides significant insights into the mechanisms underlying DN ... in DN treatment strategies targeting mTOR. Drugs such as rapamycin have demonstrated potential in preclinical models ...

Scientists at Southern University of Science and Technology in Shenzhen, China, have identified a new regulator of the mammalian target of rapamycin (mTOR) pathway associated with the growth of ...

This graphic outlines the mechanism of action of rapamycin in its ability to mimic dietary restriction and slow the aging process. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

They identified the mechanistic target of rapamycin complex 1 (mTORC1 ... in these cells at E12.5 lengthened the nasal region at E17.5. “It turns out that mTOR doesn't really change the shape, but ...

The protein was actually named after the drug: mTOR stands for mechanistic target of rapamycin. This was all 25 to 30 years ago. In the intervening couple of decades, we have learned that mTOR is a ...