eLife2d
A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception
This important study examined orientation representations along the visual hierarchy during perception and working memory. The authors provide results suggesting that during working memory there is a ...
eLife3d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
eLife4d
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
eLife3d
Activism and Science: Anne Urai and Clare Kelly on responding to the climate and biodiversity crises
Yes, identifying your audience workshop is very important. A type A audience is already engaged – they understand the urgency ...
eLife3d
Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced pain facilitation
Here, we identified a circuit, locus coeruleus descending noradrenergic neurons projecting to the spinal dorsal horn (LC →SDH -NA neurons), that is activated by acute exposure to restraint stress and ...
eLife4d
Motor unit mechanisms of speed control in mouse locomotion
This valuable study characterises the activity of motor units from two of the three anatomical subdivisions ("heads") of the triceps muscle while mice walked on a treadmill at various speeds. Although ...
eLife4d
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...
eLife4d
Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle
In this detailed study, Cohen and Ben-Shaul characterized Accessory Olfactory Bulb (AOB) cell responses to various conspecific urine samples in female mice across the estrous cycle. The authors found ...
eLife4d
Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep
Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.
eLife3d
Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...
eLife5d
Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies
An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...
eLife4d
Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...