eLife2d
A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception
This important study examined orientation representations along the visual hierarchy during perception and working memory. The authors provide results suggesting that during working memory there is a ...
eLife3d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
eLife4d
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
eLife3d
Activism and Science: Anne Urai and Clare Kelly on responding to the climate and biodiversity crises
Yes, identifying your audience workshop is very important. A type A audience is already engaged – they understand the urgency ...
eLife2d
Dorsal hippocampus mediates light-tone sensory preconditioning task in mice
This process is known as higher-order conditioning and can be measured using sensory preconditioning tasks in rodents. This behavioral paradigm requires the repeated and simultaneous presentation of ...
eLife3d
Distancing alters the controllability of emotional states by affecting both intrinsic stability and extrinsic sensitivity
Emotion regulation strategies such as distancing are a core component of many evidence-based, effective psychotherapeutic interventions. They allow individual ...
eLife4d
Motor unit mechanisms of speed control in mouse locomotion
This valuable study characterises the activity of motor units from two of the three anatomical subdivisions ("heads") of the triceps muscle while mice walked on a treadmill at various speeds. Although ...
eLife4d
Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep
Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.
eLife4d
Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle
In this detailed study, Cohen and Ben-Shaul characterized Accessory Olfactory Bulb (AOB) cell responses to various conspecific urine samples in female mice across the estrous cycle. The authors found ...
eLife3d
Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...
eLife4d
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...
eLife4d
Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness
This study presents valuable findings on the increased prevalence of pain in women with polycystic ovary syndrome and its relationship to health outcomes. The evidence supporting the conclusions is ...