此外，通过双特异性 CAR-T 细胞同时靶向 CD13 和其他抗原，有可能减少脱靶毒性，为 AML 的治疗提供了新的思路。 LILRB4：急性单核细胞白血病（FAB M5）是 AML 的一种亚型，现有治疗方法效果不佳。LILRB4 在单核细胞白血病细胞上高度表达，且在正常造血干细胞上不 ...

进一步研究表明，LILRB4可通过与载脂蛋白E（ApoE）结合，调控小胶质细胞的活动。研究人员使用携带人类LILRB4转基因且具有淀粉样蛋白β（Aβ ...

Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle cerebral artery occlusion (MCAO), but the role it plays here is not well ...

1School of Basic Medical Science, Southern Medical University, Guangzhou, China. 2Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 3Zenith Institute of ...

5 Donghai Middle Road, Qingdao, Shandong Province 266071, China; yu-jintai{at}163.com Objective We aimed to examine the association of apolipoprotein E (APOE) ɛ4 genotype with neuroimaging markers of ...

Objective: Microglia, the central nervous system's immune cells, are crucial in neuroinflammation after ischemic brain injury. Previous single-cell and spatial transcriptomics showed that LILRB4 was ...

Introduction: Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a crucial regulator of immune responses, particularly within microglia, where it may influence the infiltration of peripheral T ...

Nature Research Intelligence Topics enable transformational understanding and discovery in research by categorising any document into meaningful, accessible topics. Read this blog to understand ...