Homologous recombination (HR), the most significant event in meiosis, has important implications for genetic diversity and evolution in organisms. Heteroduplex DNA (hDNA), the product of HR, can be ...

Sensitive tissue-based detection of AR-V7 and other androgen receptor alterations using combined DNA/RNA comprehensive genomic profiling.

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Arizona State Retirement System grew its holdings in IDEAYA Biosciences, Inc. (NASDAQ:IDYA – Free Report) by 12.4% during the ...

This material on this page is ©2025 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please ...

肿瘤浸润调节性T细胞（Tumor-infiltrating regulatory T cells，TI-Treg cells）是肿瘤微环境中抑制抗肿瘤免疫并促进肿瘤进展的关键免疫细胞。尽管已有多种疗法旨在靶向TI-Treg细胞，然而大多数治疗效果不佳 ...

Colossal Biosciences has altered several genes in mice to make them look more mammoth-like, but the company is far from its ...

"This highlights a distinct mechanism of cytotoxicity, where excessive resection, rather than failed DNA repair by homologous recombination, underpins the vulnerability of BRCA-deficient cells to nick ...

Homologous recombination—a crucial meiotic event—not only enhances genetic diversity through exchanging parental genetic substances but also establishes physical connections between homologous ...

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

An extensive tumor genomic analysis of individuals with ovarian cancer, led by researchers from Huntsman Cancer Institute at ...