Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Molecular Cell. 1999). Whereas nonhomologous repair of DSBs is intact in these cells, homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

"This highlights a distinct mechanism of cytotoxicity, where excessive resection, rather than failed DNA repair by homologous recombination, underpins the vulnerability of BRCA-deficient cells to nick ...

LAE120 is a novel, allosteric and highly potent USP1 inhibitor, displaying monotherapy potency and combination activity with ...

Mayo Clinic's Precision Mouse Engineering Core in Minnesota makes embryonic stem (ES) cell-based gene-targeted mice available to researchers.