This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Here we bio-printed mesenchymal stem cells (MSCs) using a commonly used bioink sodium alginate-gelatin blends, and investigated the induction effect of MSC differentiation towards lens epithelial stem ...

Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the ...

Scientists in Cambridge have created synthetic mouse embryos in a lab, without using eggs or sperm, which show evidence of a brain and beating heart. The mouse embryos, developed using stem cells ...

Here, using intersectional genetic fate mapping, we demonstrate that cholinergic fibers within the mouse cortex exhibit remarkable laminar and regional specificity ... While early born cholinergic ...

For this, we performed lesions of the adult mouse motor cortex followed by cell transplantation of embryonic motor cortical tissues ... reminiscent of the delayed emergence of upper cortical layers ...

Cover picture: Inspired by the Review by Jung-Soon Mo, Hyun Woo Park and Kun-Liang Guan. Illustrated by Sandra Krahl.