Data was analysed using Microsoft Excel. Results Sixty-nine patients were identified, five were excluded due to age, eighteen other patients either had their loading doses given in other hospitals and ...

Alderhey.nhs.uk Introduction Phenytoin has complex pharmacokinetics. The intravenous loading dose of phenytoin for children in status epilepticus has recently been increased from 18 to 20 mg/kg. There ...

Hypotension. Severe myocardial insufficiency. Monitor ECG, BP, respiration, phenytoin levels. Diabetes. Change dose gradually. Monitor for signs/symptoms of serious dermatological reactions ...

The recovery of phenytoin from mixtures containing different phenytoin formulations and protein mixtures was studied. Three phenytoin solutions (40 mg/µL) were prepared, each in triplicate ...

Marketed formulations of extended phenytoin sodium -- long a difficult medication to titrate because of its unique absorption and saturable elimination pharmacokinetics -- may not be bioequivalent ...

Early seizure control is important to prevent neurological complications. In our centre, phenytoin loading is given if seizure control is not achieved after two doses of benzodiazepines. Issues ...

and individuals concurrently taking phenytoin tend to have higher plasma phenytoin concentrations.7 The risk of this drug reaction increases in slow acetylators.8 Moreover, our patient was taking ...

phenytoin, carbamazepine, phenobarbital, primidone), or valproate: 25mg daily for 2 weeks, then 50mg daily for 2 weeks, then 100mg daily for 1 week, then to target dose of 200mg daily. Concomitant ...

Fifteen patients (60%) continued taking phenytoin from the time of diagnosis. Mean duration of phenytoin treatment was 21 years and mean dose 350mg. Seventeen patients (68%) complained of poor balance ...