Sironax' lead RIPK1 drug, SIR0365, has completed two phase 1b studies including one looking at its potential as a treatment for severe hyperinflammation associated with COVID-19 infections, while ...

In this context, advances of both stem cell technologies and genome editing strategies during the last decade led to the generation of three-dimensional (3D) in vitro-models of cerebral organoids, ...

为探究 TBK1/IKKε 缺失时细胞死亡途径选择问题，研究发现其可限制 RIPK1 和 NLRP3 死亡通路，意义重大。 在细胞的生命活动中，细胞死亡与炎症的调控一直是生命科学领域的重要研究方向。TBK1（TANK 结合激酶 1）和 IKKε（核因子 κB 抑制因子激酶亚基 ε）这两种激酶 ...

Institute of Cancer Research UK has identified proteolysis targeting chimeras (PROTACs) comprising a Von Hippel-Lindau disease tumor suppressor (VHL) binding moiety coupled to a receptor-interacting ...

aMedical Clinic 1, Department of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany ...

It is the second disappointing readout for the biotech in the neurodegenerative disorder in the last year, coming after Sanofi-partnered RIPK1 inhibitor SAR443820 missed the mark in the HIMALAYA ...

Keywords: morphogen signalling, Hippo pathway, stem cell-derived organoids, cancer, neuronal morphology Liliana’s laboratory is ... They demonstrated that IAPs control cell death and innate immune ...

Cell ...