Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

indicating that it is not a cell-intrinsic mechanism but delivery of rapamycin to tumour cells that is impaired in some patients. As mTOR inhibitors can inhibit a negative feedback loop that ...

Purpose: The mechanism of action and pharmacokinetics of sirolimus when used as part of a drug-eluting stent (DES) and the efficacy and cost of using DESs versus bare-metal stents are discussed.

Rapamycin is used to prevent graft rejection ... at the transcriptional level through at least two independent mechanisms. mTOR was shown to limit the production of pro-inflammatory cytokines ...

This graphic outlines the mechanism of action of rapamycin in its ability to mimic dietary restriction and slow the aging process. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

Scientists at Southern University of Science and Technology in Shenzhen, China, have identified a new regulator of the mammalian target of rapamycin (mTOR) pathway associated with the growth of ...