indicating that it is not a cell-intrinsic mechanism but delivery of rapamycin to tumour cells that is impaired in some patients. As mTOR inhibitors can inhibit a negative feedback loop that ...

Rapamycin is used to prevent graft rejection ... at the transcriptional level through at least two independent mechanisms. mTOR was shown to limit the production of pro-inflammatory cytokines ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

This study provides significant insights into the mechanisms underlying DN ... in DN treatment strategies targeting mTOR. Drugs such as rapamycin have demonstrated potential in preclinical models ...

This graphic outlines the mechanism of action of rapamycin in its ability to mimic dietary restriction and slow the aging process. Disclaimer: AAAS and EurekAlert! are not responsible for the ...

Jeffrey Friedman and Kristina Hedbacker, research associate, were first authors, as was Bowen Tan (pictured below). (Credit: ...