Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

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Bucillamine and NAC will be evaluated to determine the effect on GABA(A) receptor endocytosis and the effect on diazepam effectiveness in terminating seizures. Any additional antioxidant effects on ...

This arrangement enables efficient receptor-mediated endocytosis. Local refinements of cryo-EM data identified the apoB100 β-belt as a continuous amphipathic structure wrapped around LDL’s ...

1974; Roy and Loh 1996). All these effects are mediated by the interactions of opioids with members of the opioid receptor family. Opioid binding sites were first discovered in mammalian brain ...

Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...