Actin, Spectrin, and Associated Proteins Form a Periodic ... - AAAS
2012年12月13日 · We used stochastic optical reconstruction microscopy to study the organization of actin, spectrin, and associated proteins in neurons. Actin formed ringlike structures that wrapped around the circumference of axons and were evenly spaced along axonal shafts with a periodicity of ~180 to 190 nanometers.
Structure and Organization of Actin Filaments - The Cell - NCBI …
The key protein responsible for actin filament disassembly within the cell is cofilin, which binds to actin filaments and enhances the rate of dissociation of actin monomers from the minus end. In addition, cofilin can sever actin filaments, generating …
Turn-on protein switches for controlling actin binding in cells
2024年7月11日 · Here, we describe a suite of designed proteins, Controllable Actin-binding Switch Tools (CASTs), whose actin-binding behavior can be controlled with external stimuli. CASTs were developed that...
The Actin Cytoskeleton and Actin-Based Motility - PMC
The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory proteins—is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple ...
Ion transport proteins anchor and regulate the cytoskeleton
2002年4月1日 · Structurally diverse ion transport proteins anchor the spectrin–actin cytoskeleton to the plasma membrane by binding directly to linker proteins of the ankyrin and protein 4.1 families. Cytoskeletal anchoring regulates cell shape and restricts the activity of ion transport proteins to specialised membrane domains.
The actinin family of actin cross-linking proteins – a genetic ...
2015年8月25日 · Actinins are one of the major actin cross-linking proteins found in virtually all cell types and are the ancestral proteins of a larger family that includes spectrin, dystrophin and utrophin. Invertebrates have a single actinin-encoding ACTN gene, while mammals have four.
Structural insights into actin filament turnover - Cell Press
5 天之前 · The dynamic turnover of actin filaments drives the morphogenesis and migration of all eukaryotic cells. This review summarizes recent insights into the molecular mechanisms of actin polymerization and disassembly obtained through high-resolution structures of actin filament assemblies. We first describe how, upon polymerization, actin subunits age within the filament through changes in their ...
Structural and functional mechanisms of actin isoforms
2024年5月23日 · Actin is a highly conserved and fundamental protein in eukaryotes and participates in a broad spectrum of cellular functions. Cells maintain a conserved ratio of actin isoforms, with muscle and non-muscle actins representing the main actin isoforms in muscle and non-muscle cells, respectively.
Anchoring Proteins as Regulators of Signaling Pathways
2012年8月3日 · In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology. Spatial and temporal control of signal transduction events is frequently achieved by compartmentalization of intracellular effectors through adaptors or anchoring proteins.
Actin: Structure, Function, Dynamics, and Interactions with ... - PubMed
Actin is one of the most abundant proteins in any eukaryotic cell and an indispensable component of the cytoskeleton. In mammalian organisms, six highly conserved actin isoforms can be distinguished, which differ by only a few amino acids. In non-muscle cells, actin polymerizes into actin filaments …