Actin Structure and Function - PMC - PubMed Central (PMC)
We need details of the actin ATPase, detailed structure of ADP F-actin, and detailed structure of ATP F-actin. More accurate structures of the ends of the actin filament (pointed and barbed), and the binding of capping proteins to these ends are needed.
Actin - Wikipedia
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass …
Structure and Organization of Actin Filaments
The key protein responsible for actin filament disassembly within the cell is cofilin, which binds to actin filaments and enhances the rate of dissociation of actin monomers from the minus end. In addition, cofilin can sever actin filaments, generating …
Actin: Structure, Function, Dynamics, and Interactions with
2016年11月16日 · The actin protein is composed of a single polypeptide chain of 375 amino acid residues (skeletal muscle actin) with a molecular mass of 42 kDa, whose sequence was determined by Elzinga and coworkers (1973). Its amino acid sequence is highly conserved between different organisms, and the actin protein occurs abundantly in eukaryotic cells.
Actin Structure and Function: What We Still Do Not Understand
Actin is found in two main states: G-actin (G for globular) is the monomeric form (Fig. 1), whereas F-actin (F for filamentous) is the helical polymer (Fig. 2).
Structures of the free and capped ends of the actin filament
2023年5月25日 · Actin is a key protein in cellular motility, forming filaments that give dynamic structure to cellular appendages and serve as scaffold for motor proteins. The ends of these filaments are constantly extending and dissociating, and their structure has been difficult to …
Specification of Architecture and Function of Actin Structures by Actin …
In this review, we explore the role of actin nucleation factors in constructing three different geometries of actin structures: dendritic networks, actin bundles, and isotropic networks (Figure 1). We first describe why cells require actin nucleation factors, along with the molecular mechanisms of the three main classes of actin nucleators.
Molecular Interactions of Actin: Actin Structure and Actin …
Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein.
Actin Structure and Function - Annual Reviews
Here we review structures of G-actin and F-actin and discuss some of the interactions that control the polymerization and disassembly of actin. Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and participates in more …
Actin: Structure, Function, Dynamics, and Interactions with ... - PubMed
Here, we describe the structure of monomeric and polymeric actin, the polymerization kinetics, and its regulation by actin-binding proteins. Probably due to its conserved nature and abundance, actin and its regulating factors have emerged as prefered targets of bacterial toxins and effectors, which subvert the host actin cytoskeleton to serve ...