A bibliometric analysis of programmed cell death in acute lung …
2023年9月1日 · Acute lung injury (ALI) is a prevalent critical disorder that disrupts the body's homeostasis in patients. The progression from ALI to acute respiratory distress syndrome (ARDS) is often accompanied by programmed cell death (PCD).
Ferroptosis, pyroptosis and necroptosis in acute respiratory distress ...
2023年3月10日 · Acute respiratory distress syndrome (ARDS) is an acute and uncontrolled pulmonary inflammation caused by various insults. Cell death is a critical mechanism in...
Chinese Medical Journal Pulmonary and Critical Care Medicine
2024年6月1日 · In this review, we summarized recent advances in the studies of endothelial cytoskeletal reorganization, inter-endothelial junctions, endothelial inflammation, EC death, and endothelial repair in ALI and ARDS, intending to shed some light on the potential diagnostic and therapeutic targets in the clinical management of the disease.
Acute respiratory distress syndrome heterogeneity and the septic ARDS …
2023年11月13日 · Epithelial cell death is the main feature of alveolar damage in ARDS, which can be caused by bacterial and viral infection, mechanical stretch, hypoxia and other reasons (95).
肺泡巨噬细胞死亡方式对急性呼吸窘迫综合征作用研究进展-论文
The death of alveolar macrophages (AM) plays a key regulatory role in the inflammatory response during ARDS. The death of these cells can influence other immune cell populations, promote the progression of inflammation, and create an amplified positive feedback mechanism between cell death and lung injury.
急性呼吸窘迫综合征中的铁死亡、焦亡和坏死,Cell Death …
铁死亡是一种新的细胞死亡形式，被定义为铁介导的脂质过氧化，已被证明在 ARDS 的发病机制中发挥作用。 此外，焦亡和坏死也参与了ARDS的病理生理过程。 ferroptosis、pyroptosis 和 necroptosis 之间的串扰越来越受到关注。 因此，本文将主要总结铁死亡在ARDS中的分子机制和中枢病理生理作用。 我们还将讨论我们对细胞焦亡和坏死性凋亡的理解，因为它们与 ARDS 的发病机制有关。 此外，我们还描述了参与铁死亡、细胞焦亡和坏死性凋亡之间串扰的病理过程。 …
Biomarkers, signaling pathways, and programmed cell death in …
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening, high-mortality lung diseases associated with acute and severe inflammation of the lungs. However, research on diagnostic markers and signaling pathways associated with ALI/ARDS is lacking, and no spec …
Cell death of alveolar lymphocytes and monocytes is negatively ...
2024年1月3日 · Pathogenesis of acute respiratory distress syndrome (ARDS) involves immune cell death and removal from the injured lungs. ARDS severity is related to lung compliance. However, the correlation between the respiratory mechanics and alveolar immune cell death in patients with ARDS remains unclear.
Full article: Regulated Cell Death of Alveolar Macrophages in …
In this review, we provide a comprehensive perspective on how regulated AMs death impacts on ALI/ARDS and assess its potential in new therapeutic development. Additionally, we describe the crosstalk between different RCD types in ALI, and provide new perspectives for the treatment of ALI/ARDS and other severe lung diseases.
Ferroptosis, pyroptosis and necroptosis in acute respiratory distress ...
2023年3月10日 · Acute respiratory distress syndrome (ARDS) is an acute and uncontrolled pulmonary inflammation caused by various insults. Cell death is a critical mechanism in the pathogenesis of ARDS. Ferroptosis, a novel form of cell death defined as iron-mediated lipid peroxidation, has been shown to play a role …