Potential cGAS-STING pathway functions in DNA damage responses, DNA ...
2024年1月1日 · Recently, several studies have suggested that cGAS, STING, or downstream pathway components can also regulate the DNA damage response, DNA damage checkpoint signalling, DNA repair and DNA replication. Here, I review these proposed mechanisms, and discuss some unanswered questions relating to them. 1. …
GPR162 activates STING dependent DNA damage pathway as a …
2023年2月1日 · In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes...
DNA Damage and Cancer Immunotherapy: A STING in the Tale
2020年10月1日 · Elucidating the interplay among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway activation, and anti-tumoral immunity is critical for the development of effective cancer immunotherapies.
The cGAS–cGAMP–STING pathway connects DNA damage to …
The cGAS–cGAMP–STING pathway mediates immune and inflammatory responses to cytosolic DNA. This review summarizes recent findings on how genomic instability leads to cGAS activation and how this pathway critically connects DNA damage to ...
DNA Damage and Activation of cGAS/STING Pathway Induce …
2022年2月20日 · DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses. The cGAS/STING pathway has been investigated as a critical receptor in both exogenous and endogenous DNA sensing to activate the innate immune response.
STING enhances cell death through regulation of reactive ... - Nature
2021年4月19日 · We show that STING regulates a transcriptional program that controls the generation of reactive oxygen species (ROS), and that STING loss alters ROS homeostasis to reduce DNA damage and to...
ATM inhibition enhance immunotherapy by activating STING
2024年7月20日 · Accumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the...
Targeting DNA damage response components induces enhanced STING …
2022年9月13日 · We have observed that targeting the DNA damage response in cancer cells results in the increased production of ISGs by cancer cells via a STING-dependent mechanism, the efferocytosis of drug-treated sensitive tumor cells and activation of DCs, which was enhanced in ATM-deficient tumor cells.
GPR162 activates STING dependent DNA damage pathway as a …
2023年2月1日 · In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes (STING), which targeted DNA damage responses, activated IRF3, accelerated the activation of type I interferon system, promoted the expression of ...
Activating the cGAS-STING Pathway by Manganese-Based …
19 小时之前 · In addition, it is crucial to emphasize that cisplatin-induced DNA damage can potentially trigger activation of the cGAS-STING pathway. NPMn, in combination with low-dose NPPt, a carrier of a Cis(IV) prodrug capable of causing DNA damage, augments the cGAS-STING pathway activation and significantly activates the tumor immune microenvironment ...