What Is the Role of β-Adrenergic Signaling in Heart Failure?
2003年11月14日 · Does the β-receptor system contribute to the pathogenesis of heart failure? And why are β-blockers effective in the treatment of heart failure? This review will attempt to …
Dynamics of adrenergic signaling in cardiac myocytes and …
2021年6月21日 · β 1 -adrenergic signaling dynamics in cardiomyocytes are captured by 2-variable model. Model distinguishes rate-determining processes in β 1 -adrenergic signaling …
Frontiers | Adrenergic Signaling: A Targetable Checkpoint …
Adrenergic signaling plays a vital role in promoting of metastasis (112–122) and could directly induce invasive genes such as MMPs by tumor cells and indirectly by causing cancer …
Cell swelling enhances ligand-driven β-adrenergic signaling
2024年9月7日 · We observe that in osmotically swollen cells the β2-adrenergic receptor, a prototypical GPCR, favors an active conformation, resulting in cAMP transient responses to …
β-adrenergic receptor signaling mediated by β-arrestins and its ...
2024年2月1日 · We summarize the signaling mechanisms of the catecholamine-binding β-adrenergic receptors (β-ARs), with an emphasis on the role of β-arrestins. β-ARs, a subset of …
Adrenergic regulation of immune cell function and inflammation
Immune cells respond by activation of adrenergic receptors, primarily the β2-adrenergic receptor, which signal through heterotrimeric G-proteins. Depending upon the cell type, adrenergic …
The Cardiac β-Adrenoceptor–Mediated Signaling Pathway and Its ...
1997年3月1日 · The β-AR is the first element in the signal transduction chain mediating adrenergic stimulation of the heart. All known subtypes of β-ARs (β 1 , β 2 , and β 3 ) are …
Dynamics of adrenergic signaling in cardiac myocytes and
2021年6月21日 · We reduce a detailed computational model of the β 1-adrenergic signaling cascade to a system of two differential equations by eliminating extraneous variables and …
Role of α- and β-adrenergic signaling in phenotypic targeting ...
2021年7月20日 · In this review we discuss the current evidence on (a) the signaling events of the autonomic nervous system mediated by its cognate α- and β-adrenoceptors in regulating the …
Editorial Overview: Adrenergic signaling in cellular physiology …
2024年12月1日 · Overall, AR signaling is fundamental to cellular physiology during normal conditions, and more importantly, ARs and signaling through these receptors are critical during …