Akt/PKB signaling pathway - Wikipedia
The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are …
Akt, FoxO and regulation of apoptosis - ScienceDirect
2011年11月1日 · Akt and FoxOs regulate cell growth and survival. FoxOs are involved in regulating nutrient metabolism by insulin-Akt axis. FoxOs regulate cell cycle and apoptosis …
FOXO Signaling Pathways as Therapeutic Targets in Cancer
The most important pathway interacting with FOXO in different types of cancers is the PI3K/AKT pathway. Some other important pathways such as the Ras-MEK-ERK, IKK and AMPK …
Akt, FoxO and regulation of apoptosis - PubMed
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation. Emerging evidence suggests involvement of FoxOs in …
FoxO signaling pathway - Homo sapiens (human) - GenomeNet
A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in …
FoxO transcription factors; Regulation by AKT and 14-3-3 ...
2011年11月1日 · AKT was identified in early genetic and biochemical studies as a main regulator of FoxO function in diverse organisms. Though other FoxO regulatory pathways and …
Therapeutic strategies targeting FOXO transcription factors
2020年11月10日 · The PI3K–AKT signalling pathway provides the most important inhibitory input to FOXO activity, while cellular stress signalling activates FOXO proteins 6.