Potential cGAS-STING pathway functions in DNA damage responses, DNA ...
2024年1月1日 · Recently, several studies have suggested that cGAS, STING, or downstream pathway components can also regulate the DNA damage response, DNA damage checkpoint …
GPR162 activates STING dependent DNA damage pathway as a …
2023年2月1日 · In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the …
DNA Damage and Cancer Immunotherapy: A STING in the Tale
2020年10月1日 · Elucidating the interplay among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway activation, and anti …
The cGAS–cGAMP–STING pathway connects DNA damage to …
The cGAS–cGAMP–STING pathway mediates immune and inflammatory responses to cytosolic DNA. This review summarizes recent findings on how genomic instability leads to cGAS …
DNA Damage and Activation of cGAS/STING Pathway Induce …
2022年2月20日 · DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong …
STING enhances cell death through regulation of reactive ... - Nature
2021年4月19日 · We show that STING regulates a transcriptional program that controls the generation of reactive oxygen species (ROS), and that STING loss alters ROS homeostasis to …
ATM inhibition enhance immunotherapy by activating STING
2024年7月20日 · Accumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the immunogenicity …
Targeting DNA damage response components induces enhanced STING …
2022年9月13日 · We have observed that targeting the DNA damage response in cancer cells results in the increased production of ISGs by cancer cells via a STING-dependent …
GPR162 activates STING dependent DNA damage pathway as a …
2023年2月1日 · In this study, we confirmed that GPR162, an orphan receptor in the G-protein-coupled receptor family, acted as a novel radiotherapy sensitizer by interacting with the …
Activating the cGAS-STING Pathway by Manganese-Based …
16 小时之前 · In addition, it is crucial to emphasize that cisplatin-induced DNA damage can potentially trigger activation of the cGAS-STING pathway. NPMn, in combination with low-dose …