Fragment crystallizable region - Wikipedia
The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This region allows antibodies to activate the immune system, for example, through binding to …
Fc receptor - Wikipedia
Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity.
Fc-Engineered Therapeutic Antibodies: Recent Advances and …
Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions.
Antibody Structure | Absolute Antibody
While one part of the antibody, the antigen binding fragment (Fab), recognizes the antigen, the other part of the antibody, known as the crystallizable fragment (Fc), interacts with other elements of the immune system, such as phagocytes or components of the complement pathway, to promote removal of the antigen.
Fc-Engineered Antibodies with Enhanced Fc-Effector Function for …
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies (Figure 1B).
The Role of Fc Receptors on the Effectiveness of Therapeutic …
The human FcRs belong to the Ig superfamily and are type I transmembrane glycoproteins, which bind to the Fc tail of antibodies. They comprise receptors for all five antibody classes: FcµR (IgM), FcγR (IgG), FcαR (IgA), FcδR (IgD), and FcεR (IgE) [2,8,9].
Fc-Engineered Therapeutic Antibodies: Recent Advances and …
2023年9月28日 · Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions.
Fcγ receptors as regulators of immune responses - Nature
In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in...
Beyond neutralization: Fc-dependent antibody effector ... - Nature
2022年12月19日 · Several reductionist models investigating the protective mechanisms of passively transferred monoclonal antibodies have reported an important role for non-neutralizing (crystallizable fragment...
Boosting therapeutic potency of antibodies by taming Fc …
2019年11月18日 · In this report, we review Fc engineering efforts to improve therapeutic potency, and propose future antibody engineering directions that can fulfill unmet medical needs.