Machine learning analysis of whole mouse brain vasculature
2020年3月11日 · By using VesSAP, we analyzed the vascular features of whole C57BL/6J, CD1 and BALB/c mouse brains at the micrometer scale after registering them to the Allen mouse brain atlas. We report...
The Anatomy of the Laboratory Mouse - The Jackson Laboratory
Blood vessels of the neck. 101. Blood vessels of right hind limb. Medial aspect. 102. Blood vessels of lower right hind limb. 103. Upper surface of right hind foot. 104. Under surface of right hind foot. 105. Skin removed from dorsal surface of right hind limb. 106. Blood vessels of axilla. 107. Blood vessels of left fore-limb. 108. Left manus.
An analysis modality for vascular structures combining tissue …
2022年9月12日 · In our current study, α-SMA, which is expressed in the pericytes covering the blood vessels, is used as a marker of mature blood vessels in mouse brain and VE-cadherin as a marker of...
3D morphological analysis of the mouse cerebral vasculature: …
We compared in vivo and ex vivo 2PFM in mice, focusing on apparent differences in microvascular signal and morphology. Following in vivo imaging, the mice (four total) were perfused with a fluorescent gel and their brains fructose-cleared. The brain regions imaged in vivo were imaged ex vivo.
Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of …
2017年12月18日 · To construct a standard mouse cerebral vascular system atlas to benefit studies of cerebral vascular diseases and cerebral vascular development, we acquired datasets containing both the vessels and cytoarchitecture of the whole mouse brain with a voxel resolution of 1 μm using modified Nissl staining and MOST imaging.
Visualization and molecular characterization of whole-brain …
2020年2月27日 · SeeNet is capable of whole-brain visualization of molecularly characterized cerebral vasculatures at the single-microvessel level. Moreover, SeeNet reveals a hitherto unidentified vascular pathway...
Blood and lymphatic vascular tube formation in mouse
2014年7月1日 · We describe the mechanisms of blood and lymphatic vessel formation in mouse. Cell polarity establishment, junctional remodelling, cell-ECM contacts and cell shape changes are key for blood vessel formation.
In vivo whole brain microvascular imaging in mice using …
2022年1月19日 · Imaging of cerebral microvascular vessels was achieved over the whole brain and across a large range of vessels from 20 to 200 µm and flow velocities from ∼2 to 100 mm/s. Apart from its fine spatial resolution and mapping of the whole cerebral vasculature, 3D ULM enables quantification of flow velocity, vessel diameter and flow rate.
Molecular Imaging of Vessels in Mouse Models of Disease
Vascular imaging of angiogenesis in mouse models of disease requires multi modal imaging hardware capable of targeting both structure and function at different physical scales. The three dimensional (3D) structure and function vascular information allows for accurate differentiation between biological processes.
The mouse retina in 3D: quantification of vascular growth and ...
The mouse retina has become a prominent model for studying angiogenesis. The easy access and well-known developmental progression have significantly propelled our ability to examine and manipulate blood vessels in vivo. Nonetheless, most studies have restricted their evaluations to the superficial plexus (an upper vascular layer in contact with ...