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2024年10月11日 · Annals of the Rheumatic Diseases (ARD) is an international peer-reviewed journal committed to promoting the highest standards of scientific exchange and education.
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2024年12月20日 · Efficacy, safety and tolerability of GSK3858279, an anti-CCL17 monoclonal antibody and analgesic, in healthy volunteers and patients with knee osteoarthritis pain: a phase I, randomised, double-blind, placebo-controlled, proof-of-mechanism and proof-of-concept study
About - Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases (ARD) is an international peer review journal committed to promoting the highest standards of scientific exchange and education. It covers all aspects of rheumatology, which includes the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders.
Therapeutic interception in individuals at risk of rheumatoid …
2024年9月23日 · Multiple clinical trials for rheumatoid arthritis (RA) prevention have been completed. Here, we set out to report on the lessons learnt from these studies. Researchers who conducted RA prevention trials shared the background, rationale, approach and outcomes and evaluated the lessons learnt to inform the next generation of RA prevention trials. Individuals at risk of RA can be identified ...
Cure as a treatment target in rheumatoid arthritis and systemic ...
2024年11月12日 · The past 25 years have witnessed a remarkable revolution in outcomes for patients living with rheumatoid arthritis (RA). Historically, uncontrolled joint inflammation was commonplace leading to inexorable joint destruction, disability and mortality. In contrast, well over half of patients diagnosed with RA in the modern era can now achieve disease remission through a combination of early ...
Efficacy and safety of first-line biological DMARDs in rheumatoid ...
Objective To evaluate the efficacy and safety of first-line biological disease-modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) with chronic kidney disease (CKD), including those undergoing haemodialysis (HD). Methods This retrospective cohort study included 425 patients with RA prescribed their first …
Vascular occlusion for optimising the functional improvement in ...
2024年10月30日 · Objectives Knee osteoarthritis (KOA) is a leading cause of global disability with conventional exercise yielding only modest improvements. Here we aimed to investigate the benefits of integrating blood flow restriction (BFR) into traditional exercise programmes to enhance treatment outcomes. Methods The Vascular Occlusion for optimizing the Functional Improvement in patients with Knee ...
Safety of synthetic and biological DMARDs: a systematic literature ...
Objectives To perform a systematic literature review (SLR) concerning the safety of synthetic(s) and biological (b) disease-modifying antirheumatic drugs (DMARDs) to inform the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis (RA). Methods SLR of observational studies comparing safety outcomes of any DMARD with another intervention in RA. A comparator group ...