Clathrin - Wikipedia
Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. [1] It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they …
Molecular Structure, Function, and Dynamics of Clathrin …
This review describes the structure of clathrin-coated vesicles and introduces the major components that interact to organize clathrin-mediated endocytosis. Based on direct observations of processes in the canonical pathway at the plasma membrane, we outline events that occur during the genesis of clathrin-coated pits and vesicles.
Molecule of the Month: Clathrin - RCSB: PDB-101
Clathrin cages are composed of symmetrical three-legged components called triskelions. The structure shown here, PDB entry 1xi4 , is built of 36 triskelia, one of which is highlighted in green. When triskelia snap together in solution, they can interact with enough flexibility to form either 6-sided rings that yield a flatter surface, or 5 ...
Architecture of the AP2/clathrin coat on the membranes of clathrin ...
2020年7月22日 · Clathrin-mediated endocytosis (CME) is crucial for modulating the protein composition of a cell’s plasma membrane. Clathrin forms a cage-like, polyhedral outer scaffold around a vesicle, to which cargo-selecting clathrin adaptors are attached. Adaptor protein complex (AP2) is the key adaptor in CME.
Clathrin - an overview | ScienceDirect Topics
Clathrin is the prototype self-assembling protein that coats transport vesicles during membrane traffic. Its ability to polymerize into a polyhedral lattice contributes to organization and sorting of integral membrane proteins during receptor-mediated endocytosis, organelle biogenesis, and selected recycling pathways and degradation pathways.
Clathrin: the molecular shape shifter - PubMed
2021年8月27日 · In this review, we discuss clathrin structure and coated vesicle formation, how clathrin is utilised within different cellular processes including synaptic vesicle recycling, hormone desensitisation, spermiogenesis, cell migration and mitosis, and how clathrin's remarkable 'shapeshifting' ability to form diverse lattice structures might ...
Structure and Assembly of Clathrin Cages - PubMed
The unusual structure of clathrin, combined with its ability to assemble and disassemble rapidly in cells provides a model system for us to learn about the ways in which proteins can contribute mechanically to a functioning cell. In this article, we discuss the structural properties of …
Life of a clathrin coat: insights from clathrin and AP structures
2006年1月1日 · In recent years, the determination of structures of clathrin assemblies by electron microscopy, of domains of clathrin and of its adaptors has improved our understanding of the molecular...
Molecular structure, function, and dynamics of clathrin-mediated ...
2014年5月1日 · Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate i …
The structures of natively assembled clathrin-coated vesicles
Clathrin is a 190-kDa protein with an N-terminal WD40 β-propeller domain (residues 1 to 330) followed by three helical zigzag domains in the shape of a leg and a C-terminal trimerization domain that assembles a clathrin triskelion (fig. S1, A and B), which is, in turn, the basic assembly unit of the clathrin cage.