Dystrophin - Wikipedia
Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to other support proteins that reside on the inside surface of each muscle fiber's plasma membrane (sarcolemma).
The Dystrophin Complex: structure, function and implications for ...
Dystrophin-glycoprotein complex (DGC). Dystrophin is a rod shape protein that links intracellular cytoskeleton network to transmembrane components of the DGC, including dystroglycan, sarcoglycans and sarcospan.
Dystrophin - an overview | ScienceDirect Topics
Dystrophin is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin–glycoprotein complex, which bridges the inner cytoskeleton (F-actin) and the extracellular matrix.
The role of the dystrophin glycoprotein complex in muscle cell ...
2022年9月27日 · Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix...
The role of the Dystrophin Glycoprotein Complex on the …
The Dystrophin Glycoprotein Complex (DGC) is a large multi-protein complex that links cytoskeleton actin to the extracellular matrix. This complex is critical in maintaining the structural integrity of muscle fibers and the stability of the neuromuscular synapse.
Dystrophin - an overview | ScienceDirect Topics
Dystrophin is a large protein that localizes to the cytoplasmic face of skeletal and cardiac muscle membranes. Dystrophin binds to filamentous actin at the amino terminus and to β-dystroglycan at the carboxy terminus.
Structure and Function of the Dystrophin-Glycoprotein Complex
Since its description, the dystrophin-glycoprotein complex has emerged as an important structural unit of muscle and also as a critical nexus for understanding muscular dystrophies arising from defects in several distinct genes.
The Dystrophin Complex: Structure, Function, and Implications for ...
2015年7月1日 · The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of function mutations in the genes encoding dystrophin, or the associated proteins, trigger instability of the plasma membrane, and myofiber loss.
Dystrophin - an overview | ScienceDirect Topics
Dystrophin is a large protein encoded by a gene on the X chromosome, crucial for linking F-actin to the sarcolemma in muscle cells. Deficiency of dystrophin leads to loss of structural integrity of muscle membranes, resulting in muscle fiber damage and various muscular dystrophies.
Dystrophin | definition of dystrophin by Medical dictionary
A protein found in the sarcolemma of normal muscle; it is missing in people with pseudohypertrophic muscular dystrophy and in other forms of muscular dystrophy; its role may be in the linkage of the cytoskeleton of the muscle cell …