Nociceptor - Wikipedia
A nociceptor (from Latin nocere 'to harm or hurt'; lit. 'pain receptor') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1][2][3] to the spinal cord and the brain.
Nociceptors: the sensors of the pain pathway - PMC - PubMed …
Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers.
Physiology, Nociceptive Pathways - StatPearls - NCBI Bookshelf
2022年9月26日 · Nociception refers to the central nervous system (CNS) and peripheral nervous system (PNS) processing of noxious stimuli, such as tissue injury and temperature extremes, which activate nociceptors and their pathways.
Physiology, Nociception - StatPearls - NCBI Bookshelf
2023年5月1日 · Acute noxious stimuli (e.g., heat, cold, mechanical force, or chemical stimulation) trigger nociceptors. Acute pain becomes inflammatory pain when the noxious stimulus persists long enough to allow nociceptive neurons to release their pro-inflammatory markers and sensitize or activate responsive cells in their local environment.
Nociceptor Sensory Neuron-Immune Interactions in Pain and …
Nociceptors are a specialized subset of sensory neurons that mediate pain and densely innervate peripheral tissues including the skin, joints, respiratory, and gastrointestinal tract. Various subsets of nociceptors exist, and can respond to mechanical, chemical or thermal noxious stimuli (Box 1).
Neuroanatomy of the nociceptive system: From nociceptors to brain …
We describe three main compartments of the nervous system that underlie normal nociception and the resulting pain percept: Peripheral, Spinal Cord, and Brain. We focus on how ascending nociceptive processing streams traverse these anatomical compartments, culminating in the multidimensional experience of pain.
Advances in understanding nociception and neuropathic pain
2024年10月17日 · Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which serves no protective ...
Nociceptors - Neuroscience - NCBI Bookshelf - National Center …
The relatively unspecialized nerve cell endings that initiate the sensation of pain are called nociceptors (noci-is derived from the Latin for “hurt”) (see Figure 9.2). Like other cutaneous and subcutaneous receptors, they transduce a variety of stimuli into receptor potentials, which in turn trigger afferent action potentials.
Nociceptors: the sensors of the pain pathway - PubMed
Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers …
Studying human nociceptors: from fundamentals to clinic | Brain ...
2021年6月21日 · Studying human nociceptors has revealed new therapeutic targets for the suppression of chronic pain and enhanced repair. Cellular models of human nociceptors have enabled the screening of small molecule and gene therapy approaches on nociceptor function, and in some cases have enabled correlation with clinical outcomes.